Oxidized mitochondrial DNA released after inflammasome activation is a disease biomarker for myelodysplastic syndromes
نویسندگان
چکیده
منابع مشابه
Molecular disease monitoring using circulating tumor DNA in myelodysplastic syndromes.
The diagnosis and monitoring of myelodysplastic syndromes (MDSs) are highly reliant on bone marrow morphology, which is associated with substantial interobserver variability. Although azacitidine is the mainstay of treatment in MDS, only half of all patients respond. Therefore, there is an urgent need for improved modalities for the diagnosis and monitoring of MDSs. The majority of MDS patients...
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Etiology of myelodysplastic syndromes The models for the development of sporadic MDS suggest the role of cumulative environmental exposures in genetically predisposed individuals. There is increasing evidence for a complex genetic predisposition to MDS involving naturally occurring DNA polymorphisms in genes that mediate DNA repair and metabolize environmental carcinogens.3 Large epidemiologic ...
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ژورنال
عنوان ژورنال: Blood Advances
سال: 2021
ISSN: 2473-9529,2473-9537
DOI: 10.1182/bloodadvances.2020003475